Optimal treatment for women with a Persisting Pregnancy of Unknown Location- a Randomization Clinical Trial of women at risk for an ectopic pregnancy: Active Treatment versus Expectant Management (No Treatment) The "ACTorNOT TRIAL"
This is a randomized controlled trial to compare three currently available management strategies for women with a persisting pregnancy of unknown location (PPUL), which makes them at-risk for ectopic pregnancy. This is for stable women with a confirmed PPUL to be randomized to one of three strategies:
- Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non-visualized ectopic pregnancy)
- Empiric treatment with MTX for all
- Expectant management
Recruiting from clinical population only
Dr. Kurt Barnhart, MD, MSCE